All projects need to be reviewed by a research ethics committee and you must get permission from all NHS organisations where you will be conducting your research.

Do you know where to start and what to consider in relation to ethics in your research project? The National Research Ethics Service (NRES) has a section on Do you need ethical approval? included with other frequently asked questions.

Applying to a Research Ethics Committee

Research Ethics Committees (RECs) have been working to standard operating procedures since 1st March 2004. NRES gives people access to comprehensive and up-to-date information on the REC system in the UK including Guidance for applicants.

There is a standard NHS REC application form and you need to register before you can complete it. (Register once, and you can fill in as many applications as you like)

A new Integrated Research Application System (IRAS) was recently launched.

Applying to NHS Organisations for R&D Approval

The NHS R&D Forum provides guidance to applying for R&D approval from the NHS.

There is a standard Site Specific Information form (SSI), to apply to NHS organisations. This form is linked to the standard NHS REC application form. The SSI form needs to be completed for all studies taking place in the NHS.

• Contact your Trust R&D Department  

Your R&D Department, RDDirect and the RDSU and Regional sources of advice may be able to help you with the application process.

Prepare your information sheet and consent form

How do you fill out ethical consent forms?

• Information Sheet checklist
• Consent form

Ensure your participant information meets the needs of those using it:

• RNIB clear print guidelines
• Medicines for Children Research Network - See Patients & Families section
• UK Connect – general advice about literature for people with aphasia

Research Governance

What is research governance? How does it affect me?

• Research Governance including the Research Governance Framework
• The UK Medical Research Council and Department of Health have developed a Clinical Trials Toolkit for use in all publicly funded academic trials. This includes guidance on Good Clinical Practice.
• The UKCRN Regulatory and Governance Advice Service publishes information on regulatory and governance events and news, as well as a series of Questions and Answers